#Mamypoko Hello Doctor, I feel It is important to change diapers every two to three hours. Keeping the baby longer than this period with a used diaper can cause infections or rashes. When the baby passes stool, then it is a must to change the diaper immediately to maintain hygiene. It is not safe to have the baby in diapers for 24 hours. Whenever you are changing diapers, give 15-20 minutes of open air time to let the skin dry on its own.