Taking Labetalol in Pregnancy: Is It Safe, Risks & Side Effects

Taking Labetalol During Pregnancy – Is It Safe?

Medically Reviewed By
Dr. Rima Sonpal (Gynecologist/Obstetrician)
View more Gynecologist/Obstetrician Our Panel of Experts

Pregnancy is a time when you need to stay in good health to keep all the complications at bay. It is a well-known fact that labetalol is considered effective in lowering high blood pressure during pregnancy, but one must remain very careful about its probable side-effects as well. It slows the heart rate and improves blood flow, thus decreasing blood pressure. However, it does not cure it. The drug is only a part of the complete treatment for high blood pressure, which includes exercise, diet, and overall weight control. Hence, as a precautionary measure, one must know all about the medicine.

What Is Labetalol?

Labetalol is a drug used for treating high blood pressure. This medication is termed ‘beta-blocker’ – a group of drugs that can be given orally for long-term hypertension management and intravenously in severe hypertensive situations. Lowering blood pressure helps prevent heart attacks, strokes, and kidney problems. It relaxes the blood vessels and slows the heart rate, which results in improved blood flow, thus decreasing blood pressure.

Is It Safe to Take Labetalol During Pregnancy?

High blood pressure or hypertension is a serious concern for women during pregnancy. It can sometimes cause severe health complications for the mother and the developing baby.

Labetalol for high blood pressure during pregnancy is prescribed to women who have high blood pressure during pregnancy (pregnancy-induced hypertension or gestational hypertension). High blood pressure can lead to damaged kidneys, brain, heart and blood vessels, if not treated promptly. If these organs are affected, it may lead to heart disease, heart failure, heart attack, kidney failure, loss of vision, or stroke.

Sometimes, women who are being treated for high blood pressure before pregnancy are made to switch to labetalol from their previous medicine. It also depends on how many weeks pregnant the patient is. It is, therefore, important to weigh how necessary labetalol is to your health against any possible risk that you or your baby might be in. Ultimately, the decision to start, stop, continue or change any medicine should be made in consultation with your healthcare provider.

Why Is Labetalol Used During Pregnancy?

A pregnant woman taking medication.

  • To control high blood pressure for the health of the unborn baby and the mother.
  • It can be used as an acceptable oral antihypertensive agent as it is safe for mothers with high blood pressure. It is a recommended drug and doesn’t affect the unborn child if taken during pregnancy
  • Labetalol for high blood pressure during pregnancy is instrumental in causing a smooth and sustained fall in blood pressure and is free of any grievous side-effects.
  • Labetalol supersedes all other medicines as a first-line drug and can be safely taken in the first trimester of pregnancy.

Side-Effects and Risks of Taking Labetalol During Pregnancy

It has been generally observed that older adults are more sensitive to the side-effects of the drug. It is not necessary that a side-effect will definitely occur, but if it occurs, it may need medical attention. Though labetalol is often prescribed to expectant ladies, some common side-effects are as follows:

  • Taking the medicine in very high doses daily causes fatigue.
  • A regular dosage of the medicine can, in some rare cases, cause an upset stomach.
  • Some rare cases also experience a stuffy nose as a side-effect.
  • Sometimes, it might cause tingling in the scalp or skin, especially in temporary doses.
  • Some patients have also reported dizziness and drowsiness after consuming the medicine daily.

Some side-effects of the medication do not need any medical attention. As the body gradually gets accustomed to the medicine, the side-effects disappear. Even the healthcare provider gives useful guidance to prevent or reduce the side-effects of the medicine. If any side-effect happens to be bothersome, the health care provider must soon be consulted.

Things You Need to Be Careful About

Labetalol is safe as a medicine for hypertension. Nevertheless, one should be careful before taking the medicine and follow the instructions given by the doctor.

  • Do not stop taking the medicine suddenly.
  • If it is discontinued suddenly, it increases blood pressure.
  • Avoid taking the medicine if you are allergic to it.
  • Discontinue taking it if you have a second or third-degree heart block or very slow heartbeat.
  • Do not take the medicine if you have any kidney or liver disease, diabetes or allergies.


As high blood pressure during pregnancy is a common symptom, there are bound to be many questions that need to be answered to understand it well. In order to alleviate some of the anxieties related to it, you might feel delighted to know about the frequently asked questions related to the use of labetalol during pregnancy.

  • Is labetalol available as a generic drug?
  • Do I need a prescription for labetalol?
  • Are there drugs and supplements that interact with labetalol?
  • What else should be known about labetalol?
  • What special dietary instructions should one follow?

Here are some more:

1. What If I Already Consumed Labetalol When Pregnant?

Consult a doctor if you have taken any medicine when already pregnant. The doctor will then decide whether the medicine is still required or you should discontinue it. The doctor will also determine the lowest labetalol dose in pregnancy that will work so that it is safe for you as well as the unborn baby.

2. Can Consuming Labetalol Cause the Baby to Be Born With Birth Defects?

Since most of the baby’s internal organs develop within the first 3 months (12 weeks) of pregnancy, any risk of birth defects will be higher at this time. Only a few studies have been conducted to identify if conditions like hypospadias or heart defects are linked to consumption of labetalol during pregnancy. The studies do not show any such link between labetalol and these defects at present. In short, labetalol doesn’t cause any effects to the baby hence given safely

3. Can Consuming Labetalol When Pregnant Cause Miscarriage?

One of the most common pregnancy-related issues is miscarriage. It is the spontaneous loss of the baby in the first 20 weeks of pregnancy. Miscarriage due to the use of a particular drug is very rare.

There are no assessments on miscarriage after consuming labetalol. Very little evidence of miscarriages proves that it is one’s personal health status which is equally responsible for any such unfortunate eventuality.

4. Does Labetalol Cause Stillbirth?

Losing a baby is a terrible emotional blow. A baby who is born without any signs of life after 24 weeks of pregnancy is called a stillborn child. The mother ‘s health, age, lifestyle, and certain genetic factors are some of the reasons for it.

Labetalol does not cause stillbirth. There is a higher risk of stillbirth when the blood pressure of the pregnant mother is poorly controlled. Though there are cases where women taking labetalol experienced stillbirth, there are others who had a completely safe delivery. It is the high blood pressure that causes the risk of stillbirth and not labetalol, which actually alters the risk.

5. Does Labetalol Cause Preterm Birth (Before 37 Week), If Taken in Pregnancy?

Labetalol and pregnancy are absolutely common. Preterm delivery is sometimes medically induced by the doctor due to concerns about the baby’s health in the womb or because of the severity of the expectant mother’s high blood pressure. Therefore, it cannot definitely be concluded that the medicines that are used to treat high blood pressure during pregnancy are actually responsible for preterm delivery. Some studies of preterm birth rate were conducted, in which it was found that taking labetalol during pregnancy is not linked to an increased risk of preterm birth.

6. Can Consuming Labetalol in Pregnancy Cause Low Birth Weight?

Many of the studies that were conducted on expectant mothers found no evidence that taking labetalol during pregnancy increased the risk of low birth weight in the baby. It is high blood pressure that causes less birth weight and not labetalol.

7. Can Taking Labetalol Cause other Health Problems in the Newborn Child?

It is absolutely uncertain whether a labetalol dose in pregnancy can affect the baby after birth. There are some known side-effects of a labetalol dose in pregnancy, like low heart rate, low blood pressure, and low blood sugar. Sometimes, these effects are found in babies who were exposed to labetalol in their mother’s womb. However, a number of studies have suggested that the likelihood of any complication with the baby after birth is not due to the exposure of the baby to labetalol in the mother’s womb. Therefore, mothers who have been taking labetalol during pregnancy should arrange for the baby to be born in a unit where the baby can be well-monitored and treated for a few hours or days after birth if required.

8. Is There a Need for Extra Monitoring for Me and Baby During Pregnancy or After Delivery?

When women with high blood pressure deliver their baby, they are usually offered special care and are closely monitored to ensure that their blood pressure is in the correct range and their baby is developing and growing at a normal pace. Most expectant mothers, as part of their antenatal care, are offered a scan at around 20 weeks of pregnancy to determine any birth defects in the foetus. Women who used labetalol in the later stages of pregnancy should ensure appropriate medical intervention and support if the baby shows any signs of adverse effects of ‘beta-blocker’ exposure.

Labetalol and pregnancy are not at all uncommon. One must also know that every pregnancy is unique. It is suggested to all expectant mothers to keep a record of all the medication undertaken during pregnancy in a handheld maternity record so that the doctor can see the medical history of the patient at a glance.

Resources and References: MedicineNet

Also Read: Fast Heart Beat during Pregnancy

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